Quetiapine v. lithium in the maintenance phase following a first episode of mania: Randomised controlled trial

M Berk; R Daglas; O Dandash; M Yücel; L Henry; K Hallam; C Macneil; M Hasty; C Pantelis; BP Murphy; L Kader; S Damodaran; MTH Wong; P Conus; A Ratheesh; PD McGorry; SM Cotton

Journal article

Quetiapine v. lithium in the maintenance phase following a first episode of mania: Randomised controlled trial

M Berk, R Daglas, O Dandash, M Yücel, L Henry, K Hallam, C Macneil, M Hasty, C Pantelis, BP Murphy, L Kader, S Damodaran, MTH Wong, P Conus, A Ratheesh, PD McGorry, SM Cotton

British Journal of Psychiatry | ROYAL COLLEGE OF PSYCHIATRISTS | Published : 2017

DOI: 10.1192/bjp.bp.116.186833

Abstract

Background Lithium and quetiapine are considered standard maintenance agents for bipolar disorder yet it is unclear how their efficacy compares with each other. Aims To investigate the differential effect of lithium and quetiapine on symptoms of depression, mania, general functioning, global illness severity and quality of life in patients with recently stabilised first-episode mania. Method Maintenance trial of patients with first-episode mania stabilised on a combination of lithium and quetiapine, subsequently randomised to lithium or quetiapine monotherapy (up to 800 mg/day) and followed up for 1 year. (Trial registration: Australian and New Zealand Clinical Trials Registry - ACTRN1260700..

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University of Melbourne Researchers

Michael Berk Author

Orwa Dandash Author

Christos Pantelis Author

Aswin Ratheesh Author

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Grants

Awarded by Brain and Behavior Research Foundation

Funding Acknowledgements

This study was supported by an unrestricted grant from Astra Zeneca. M.Y. is supported by a National Health and Medical Research Council (NHMRC) Senior Research Fellowship 1021973 and Principal Research Fellowship (1117188). S.M.C. is supported by a NHMRC Career Development Fellowship 1061998. M.B. is supported by a NHMRC Senior Principal Research Fellowship 1059660. P.D.M. is supported by a NHMRC Senior Principal Research Fellowship. C.P. was supported by a NHMRC Senior Principal Research Fellowship (628386 and 1105825) and a Brain and Behavior Research Foundation (NARSAD) Distinguished Investigator Award (US; Grant ID: 18722) and he has received major support from NHMRC and the Australian Research Council (ARC), as well as Melbourne Health and The University of Melbourne.